Endocrine Abstracts

Tissue and cell type specific control of glucocorticoid receptor (GR) levels is thought to occur through the usage of alternate promoters, and associated non-coding alternate first exons. The vast majority of the known alternative first exons are located within a 3.2 kbp CpG island. Methylation of certain CpG dinucleotides within the rat Gr promoter has been implicated in changes in hippocampal GR expression levels and the resultant disturbances in the HPA axis.<...